HCQS 400 mg tablets contain hydroxychloroquine sulfate, an antimalarial and disease-modifying agent used to prevent and treat malaria and manage autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. Hydroxychloroquine reduces inflammation by inhibiting lysosomal activity, modulating antigen presentation, and decreasing cytokine release. At higher 400 mg dose, it is often used as an initial or acute treatment dose before tapering to a maintenance regimen.
For acute malaria treatment in adults, hydroxychloroquine 400 mg is part of a dosing schedule that begins with an 800 mg loading dose followed by 400 mg at 6, 24, and 48 hours. For prophylaxis, 400 mg is taken once weekly starting one week before travel and continuing for four weeks after leaving the endemic area. In autoimmune diseases, 400 mg may be used initially or as a maintenance dose in heavier patients. Tablets should be taken with food or milk to minimize gastrointestinal upset, and doses may be divided if stomach irritation occurs.
Adverse effects are similar to lower doses but may be more pronounced at higher doses, including nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, or pruritus. Long-term or high-dose therapy can increase the risk of retinal toxicity and vision changes; regular eye examinations are essential. Severe but rare adverse effects include cardiomyopathy, hypoglycemia, blood dyscrasias, or neuromuscular weakness. Use caution in patients with liver or kidney dysfunction, psoriasis, porphyria, or those taking other hepatotoxic or cardiotoxic medications. Avoid combining hydroxychloroquine with other quinine or chloroquine-containing drugs to reduce the risk of overdose. Pregnant women should use this medication only when the potential benefits outweigh the risks. For comprehensive information and to obtain this medication, please visit: HCQS 400.
For acute malaria treatment in adults, hydroxychloroquine 400 mg is part of a dosing schedule that begins with an 800 mg loading dose followed by 400 mg at 6, 24, and 48 hours. For prophylaxis, 400 mg is taken once weekly starting one week before travel and continuing for four weeks after leaving the endemic area. In autoimmune diseases, 400 mg may be used initially or as a maintenance dose in heavier patients. Tablets should be taken with food or milk to minimize gastrointestinal upset, and doses may be divided if stomach irritation occurs.
Adverse effects are similar to lower doses but may be more pronounced at higher doses, including nausea, vomiting, diarrhea, abdominal pain, headache, dizziness, or pruritus. Long-term or high-dose therapy can increase the risk of retinal toxicity and vision changes; regular eye examinations are essential. Severe but rare adverse effects include cardiomyopathy, hypoglycemia, blood dyscrasias, or neuromuscular weakness. Use caution in patients with liver or kidney dysfunction, psoriasis, porphyria, or those taking other hepatotoxic or cardiotoxic medications. Avoid combining hydroxychloroquine with other quinine or chloroquine-containing drugs to reduce the risk of overdose. Pregnant women should use this medication only when the potential benefits outweigh the risks. For comprehensive information and to obtain this medication, please visit: HCQS 400.
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