Clofranil 50 mg is a moderate-strength tablet of clomipramine, a tricyclic antidepressant renowned for its efficacy in obsessive–compulsive disorder (OCD), depression and certain anxiety disorders. By blocking the reuptake of serotonin and norepinephrine, Clofranil 50 mg helps correct neurotransmitter imbalances that contribute to intrusive thoughts, compulsive behaviours, and persistent low mood. The 50‑milligram strength is often used once initial tolerability at lower doses has been established, or when a stronger therapeutic effect is required.
Patients usually start on a low dose and gradually increase under medical supervision to reduce the risk of adverse effects. Clofranil can be taken once or multiple times daily, preferably with food, to minimise gastrointestinal upset. Because clomipramine accumulates in the body, it may take several weeks to experience the full benefits; adherence to the prescribed regimen is essential. Abrupt discontinuation should be avoided, as it can lead to withdrawal symptoms such as nausea, headache, weakness, and sleep disturbances. Dose reductions should be done slowly and with a physician’s guidance.
Common side effects at this dose include drowsiness, dry mouth, constipation, dizziness, increased sweating, and blurred vision. These effects usually lessen as the body adjusts but can persist. More serious side effects include orthostatic hypotension, tachycardia, tremors, urinary retention, and changes in heart rhythm. Clomipramine may also reduce sexual desire or cause difficulty achieving orgasm. Seek medical attention immediately if you experience confusion, fever, muscle rigidity, or other signs of serotonin syndrome, seizures, or allergic reaction. Clofranil should not be combined with monoamine oxidase inhibitors, SSRIs, or other drugs that increase serotonin without medical guidance. Individuals with glaucoma, recent heart attack, seizure disorders, or urinary retention should discuss potential risks with their healthcare provider before starting treatment. Regular monitoring of heart function and blood counts may be recommended for long-term therapy. With careful management, Clofranil 50 mg can provide significant relief from the distressing symptoms of OCD and depression.
Patients usually start on a low dose and gradually increase under medical supervision to reduce the risk of adverse effects. Clofranil can be taken once or multiple times daily, preferably with food, to minimise gastrointestinal upset. Because clomipramine accumulates in the body, it may take several weeks to experience the full benefits; adherence to the prescribed regimen is essential. Abrupt discontinuation should be avoided, as it can lead to withdrawal symptoms such as nausea, headache, weakness, and sleep disturbances. Dose reductions should be done slowly and with a physician’s guidance.
Common side effects at this dose include drowsiness, dry mouth, constipation, dizziness, increased sweating, and blurred vision. These effects usually lessen as the body adjusts but can persist. More serious side effects include orthostatic hypotension, tachycardia, tremors, urinary retention, and changes in heart rhythm. Clomipramine may also reduce sexual desire or cause difficulty achieving orgasm. Seek medical attention immediately if you experience confusion, fever, muscle rigidity, or other signs of serotonin syndrome, seizures, or allergic reaction. Clofranil should not be combined with monoamine oxidase inhibitors, SSRIs, or other drugs that increase serotonin without medical guidance. Individuals with glaucoma, recent heart attack, seizure disorders, or urinary retention should discuss potential risks with their healthcare provider before starting treatment. Regular monitoring of heart function and blood counts may be recommended for long-term therapy. With careful management, Clofranil 50 mg can provide significant relief from the distressing symptoms of OCD and depression.
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